Bertoletti, Nicole Dr.
| Institut/Firma | Philipps-Universität Marburg, Fachbereich Pharmazie |
| Adresse | Institut für Pharmazeutische Chemie, Marbacher Weg 6, 35032 Marburg |
| Telefon | +49 6421 28 21339 |
| bertolet'at'staff.uni-marburg.de | |
| Arbeitsgebiet | Research Subject Structural characterization of 17ß-hydroxysteroid dehydrogenase type 14 and inhibitor structure optimization using the crystallization and computational technique. Peer-reviewed Publication • Bertoletti N,* Braun F,* Lepage M, Möller G, Adamski J, Heine A, Klebe G, Marchais-Oberwinkler S. New Insights into Human 17beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor J. Med. Chem 2016 59 (14), 6961–6967 • Braun F,* Bertoletti N,* Möller G, Adamski J, Steinmetzer T, Salah M, Abdelsamie A. S, van Koppen C. J, Heine A, Klebe G, Marchais-Oberwinkler S. First Structure-Activity Relationship of 17beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme J. Med. Chem 2016 59 (23), pp 10719–10737 _____________________________ *These authors contributed equally Conference Talks • Bertoletti N, Braun F, Zara L, Metz A, Heine A, Klebe G, Marchais-Oberwinkler S. X-ray Crystallographic Fragment Screening and Hit Optimization 25th Annual Meeting of the German Crystallographic Society, March 27-30 2017, Karlsruhe, Germany (5 min oral presentation) Conference Posters • Bertoletti N, Braun F, Zara L, Metz A, Heine A, Klebe G, Marchais-Oberwinkler S. X-ray Crystallography: Essential Tool for Protein Characterization and Ligand Optimization 24th Congress of the International Union of Crystallography, August 21-28 2017, Hyderbad, India • Bertoletti N, Braun F, Zara L, Metz A, Heine A, Klebe G, Marchais-Oberwinkler S. X-ray Crystallographic Fragment Screening and Hit Optimization 25th Annual Meeting of the German Crystallographic Society, March 27-30 2017, Karlsruhe, Germany • Bertoletti N, Zara L, Metz A, Braun F, Heine A, Klebe G, Marchais-Oberwinkler S. X-ray Crystallographic Fragment Screening for the Development of New h17beta-HSD14 Inhibitors Eighth Joint BER II and BESSY II User Meeting, December 7-9 2016, Berlin, Germany • Bertoletti N, Zara L, Metz A, Heine A, Klebe G, Marchais-Oberwinkler S. Structure and Fragment Based Lead Discovery for New Potential h17beta-HSD14 Inhibitor DPhG Jahrestagung 2016 / Annual meeting, October 4-7 2016, Munich, Germany • Bertoletti N, Braun F, Lepage M, Möller G, Adamski J, Heine A, Klebe G, Marchais-Oberwinkler S. Insight into the Structure of Human 17beta-Hydroxysteroid Dehydrogenase type 14 EFMC-ISMC 2016 XXIV EFMC International Symposium on Medicinal Chemistry, August 28 - September 1 2016 Manchester, UK • Bertoletti N, Braun F, Lepage M, Heine A, Klebe G, Marchais-Oberwinkler S. Structure of 17beta-Hydroxysteroid Dehydrogenase 14 with First-in-Class Inhibitors. (Poster prize) Seventh Joint BER II and BESSY II User Meeting, December 9-10, 2015 in Berlin, Germany • Bertoletti N, Braun F, Lepage M, Möller G, Adamski J, Heine A, Klebe G, Marchais-Oberwinkler S. Structure characterization of 17beta-hydroxysteroid dehydrogenase Type 14 and identification of the first inhibitors. DPhG Jahrestagung 2015 / Annual meeting, September 23-25, 2015 in Düsseldorf, Germany |